ai.nullary/nullary

Official35 tools

Negative results intelligence for drug discovery — query measured failures via MCP.

Query measured failures and negative results data for drug discovery research.

Captured live from the server via tools/list.

search_inactive_compounds

Inactive small-molecule compound-target pairs.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_selectivity

Small molecules that failed selectivity.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_admet_failures

Small-molecule ADMET failures.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_guides

Failed/ineffective CRISPR guides.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_essentiality_screens

Non-dependency / failed essentiality screens.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_ancestry_specific_failures

Ancestry-specific CRISPR failures.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_developability_failures

Antibody developability failures.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_clinical_antibodies

Discontinued/terminated clinical antibodies.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_peptide_therapeutics

Failed peptide therapeutics.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_peptide_stability_issues

Peptide stability/half-life failures.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_protacs

PROTACs that failed degradation/ternary/permeability.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_protac_e3_issues

PROTAC E3-ligase recruitment / ternary failures.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_oligonucleotides

ASOs/siRNAs that failed engagement/developability.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_oligo_delivery_failures

Oligonucleotide delivery failures.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_vaccines

Failed/terminated vaccines (by pathogen/indication).

Parameters (6)

targetstring
UniProt accession or gene symbol
indicationstring
disease/indication
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_vaccine_immunogenicity_failures

Failed vaccine immunogen designs.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_adcs

ADCs that failed at any stage.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_adc_linker_failures

ADC failures attributed to linker chemistry.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_bispecifics

Bispecifics that failed at any stage.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_bispecific_format_failures

Bispecific format/engineering failures.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_admet_failures_all_modalities

ADMET failures across ALL modalities.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_drug_drug_interaction_failures

Drug-drug interaction failures.

Parameters (5)

compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_mechanism_failures

Approaches that failed for a mechanism (by target).

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_failed_replications

Findings that failed to replicate.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_safety_failures

Clinical/preclinical safety failures across modalities.

Parameters (6)

targetstring
UniProt accession or gene symbol
compoundstring
compound name, ChEMBL ID, or InChIKey
outcomestring
outcome filter (inactive, failed_safety, terminated, …)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_target_history

ALL failed approaches against a target across every modality.

Parameters (4)

targetstringrequired
UniProt accession or gene symbol (required)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_indication_history

ALL failed approaches for an indication across every modality.

Parameters (4)

indicationstringrequired
indication (required)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

search_pathogen_history

Vaccine + antimicrobial + antibody failures for a pathogen.

Parameters (4)

pathogenstringrequired
pathogen name (required)
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

get_compound

A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.

Parameters (6)

inchi_keystring
Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid).
chembl_idstring
ChEMBL molecule ID, e.g. CHEMBL941.
pubchem_cidinteger
PubChem Compound ID (CID).
tierstring
Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limitinteger
Maximum number of findings to return (1–100, default 25).
offsetinteger
Number of findings to skip before this page, for pagination (default 0).

get_finding_provenance

Full provenance + detail for a single finding by id.

Parameters (1)

idstringrequired
finding UUID

get_target_landscape

Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).

Parameters (1)

targetstringrequired
gene symbol or UniProt accession (required)

list_top_targets

Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).

Parameters (2)

familystring
target family filter (optional)
limitinteger
Maximum number of findings to return (1–100, default 25).

list_models

Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.

No parameters.

get_model_card

Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).

Parameters (1)

targetstringrequired
gene symbol or UniProt accession (required)

get_coverage

Per-modality and per-source coverage stats (honest Phase-1 numbers).

No parameters.

Install

claude_desktop_config.json

{
  "mcpServers": {
    "nullary": {
      "command": "npx",
      "args": [
        "-y",
        "mcp-remote",
        "https://mcp.nullary.ai/mcp"
      ]
    }
  }
}

Desktop config is stdio-only; this bridges via mcp-remote. Native remote: Settings > Connectors.