ai.nullary/nullary

Official35 toolsLive

by nullary

Negative results intelligence for drug discovery — query measured failures via MCP.

MCP Server: ai.nullary/nullary

The ai.nullary/nullary Model Context Protocol (MCP) server provides “Negative results intelligence for drug discovery,” enabling users to query measured failures via MCP. It is identified by the slug ai-nullary-nullary and exposes 35 tools through the MCP interface.

🛠️ Key Features

Negative results intelligence for drug discovery
Query measured failures via MCP
35 tools available via the MCP server

🚀 Use Cases

Drug discovery workflows that incorporate negative outcomes
Retrieving and using measured failures during investigation

⚡ Developer Benefits

Consumes measured failure information through MCP tooling
Tool-based access pattern with a reported tool count of 35

⚠️ Limitations

Documentation provided includes a description and tool count only; no further capabilities, inputs, or constraints are specified

Captured live from the server via tools/list.

search_inactive_compounds

Inactive small-molecule compound-target pairs.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_selectivity

Small molecules that failed selectivity.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_admet_failures

Small-molecule ADMET failures.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_guides

Failed/ineffective CRISPR guides.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_essentiality_screens

Non-dependency / failed essentiality screens.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_ancestry_specific_failures

Ancestry-specific CRISPR failures.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_developability_failures

Antibody developability failures.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_clinical_antibodies

Discontinued/terminated clinical antibodies.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_peptide_therapeutics

Failed peptide therapeutics.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_peptide_stability_issues

Peptide stability/half-life failures.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_protacs

PROTACs that failed degradation/ternary/permeability.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_protac_e3_issues

PROTAC E3-ligase recruitment / ternary failures.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_oligonucleotides

ASOs/siRNAs that failed engagement/developability.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_oligo_delivery_failures

Oligonucleotide delivery failures.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_vaccines

Failed/terminated vaccines (by pathogen/indication).

Parameters6

target	string	optional	UniProt accession or gene symbol
indication	string	optional	disease/indication
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "indication": {
      "type": "string",
      "description": "disease/indication"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_vaccine_immunogenicity_failures

Failed vaccine immunogen designs.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_adcs

ADCs that failed at any stage.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_adc_linker_failures

ADC failures attributed to linker chemistry.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_bispecifics

Bispecifics that failed at any stage.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_bispecific_format_failures

Bispecific format/engineering failures.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_admet_failures_all_modalities

ADMET failures across ALL modalities.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_drug_drug_interaction_failures

Drug-drug interaction failures.

Parameters5

compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_mechanism_failures

Approaches that failed for a mechanism (by target).

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_failed_replications

Findings that failed to replicate.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_safety_failures

Clinical/preclinical safety failures across modalities.

Parameters6

target	string	optional	UniProt accession or gene symbol
compound	string	optional	compound name, ChEMBL ID, or InChIKey
outcome	string	optional	outcome filter (inactive, failed_safety, terminated, …)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol"
    },
    "compound": {
      "type": "string",
      "description": "compound name, ChEMBL ID, or InChIKey"
    },
    "outcome": {
      "type": "string",
      "description": "outcome filter (inactive, failed_safety, terminated, …)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

search_target_history

ALL failed approaches against a target across every modality.

Parameters4

target	string	required	UniProt accession or gene symbol (required)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "UniProt accession or gene symbol (required)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": [
    "target"
  ]
}

search_indication_history

ALL failed approaches for an indication across every modality.

Parameters4

indication	string	required	indication (required)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "indication": {
      "type": "string",
      "description": "indication (required)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": [
    "indication"
  ]
}

search_pathogen_history

Vaccine + antimicrobial + antibody failures for a pathogen.

Parameters4

pathogen	string	required	pathogen name (required)
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "pathogen": {
      "type": "string",
      "description": "pathogen name (required)"
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": [
    "pathogen"
  ]
}

get_compound

A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.

Parameters6

inchi_key	string	optional	Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid).
chembl_id	string	optional	ChEMBL molecule ID, e.g. CHEMBL941.
pubchem_cid	integer	optional	PubChem Compound ID (CID).
tier	string	optional	Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails).
limit	integer	optional	Maximum number of findings to return (1–100, default 25).
offset	integer	optional	Number of findings to skip before this page, for pagination (default 0).

Raw schema

{
  "type": "object",
  "properties": {
    "inchi_key": {
      "type": "string",
      "description": "Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid)."
    },
    "chembl_id": {
      "type": "string",
      "description": "ChEMBL molecule ID, e.g. CHEMBL941."
    },
    "pubchem_cid": {
      "type": "integer",
      "description": "PubChem Compound ID (CID)."
    },
    "tier": {
      "type": "string",
      "enum": [
        "curated",
        "all"
      ],
      "default": "curated",
      "description": "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    },
    "offset": {
      "type": "integer",
      "minimum": 0,
      "default": 0,
      "description": "Number of findings to skip before this page, for pagination (default 0)."
    }
  },
  "required": []
}

get_finding_provenance

Full provenance + detail for a single finding by id.

Parameters1

string

required

finding UUID

Raw schema

{
  "type": "object",
  "properties": {
    "id": {
      "type": "string",
      "description": "finding UUID"
    }
  },
  "required": [
    "id"
  ]
}

get_target_landscape

Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).

Parameters1

target

string

required

gene symbol or UniProt accession (required)

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "gene symbol or UniProt accession (required)"
    }
  },
  "required": [
    "target"
  ]
}

list_top_targets

Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).

Parameters2

family	string	optional	target family filter (optional)
limit	integer	optional	Maximum number of findings to return (1–100, default 25).

Raw schema

{
  "type": "object",
  "properties": {
    "family": {
      "type": "string",
      "description": "target family filter (optional)"
    },
    "limit": {
      "type": "integer",
      "minimum": 1,
      "maximum": 100,
      "default": 25,
      "description": "Maximum number of findings to return (1–100, default 25)."
    }
  }
}

list_models

Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.

Parameters

No parameters.

Raw schema

{
  "type": "object",
  "properties": {}
}

get_model_card

Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).

Parameters1

target

string

required

gene symbol or UniProt accession (required)

Raw schema

{
  "type": "object",
  "properties": {
    "target": {
      "type": "string",
      "description": "gene symbol or UniProt accession (required)"
    }
  },
  "required": [
    "target"
  ]
}

get_coverage

Per-modality and per-source coverage stats (honest Phase-1 numbers).

Parameters

No parameters.

Raw schema

{
  "type": "object",
  "properties": {}
}

Install

Tools (35)

search_inactive_compoundssearch_failed_selectivitysearch_admet_failuressearch_failed_guidessearch_failed_essentiality_screenssearch_ancestry_specific_failuressearch_developability_failuressearch_failed_clinical_antibodies

Remote endpoint

Streamable HTTP

Hosted server - connect over the network, no local install.

url

https://mcp.nullary.ai/mcp

Add to VS Code Add to Cursor

claude_desktop_config.json

json

{
  "mcpServers": {
    "nullary": {
      "command": "npx",
      "args": [
        "-y",
        "mcp-remote",
        "https://mcp.nullary.ai/mcp"
      ]
    }
  }
}

Desktop config is stdio-only; this bridges via mcp-remote. Native remote: Settings > Connectors.

MCP Server: ai.nullary/nullary

🛠️ Key Features

🚀 Use Cases

⚡ Developer Benefits

⚠️ Limitations

search_inactive_compounds

search_failed_selectivity

search_admet_failures

search_failed_guides

search_failed_essentiality_screens

search_ancestry_specific_failures

search_developability_failures

search_failed_clinical_antibodies

search_failed_peptide_therapeutics

search_peptide_stability_issues

search_failed_protacs

search_protac_e3_issues

search_failed_oligonucleotides

search_oligo_delivery_failures

search_failed_vaccines

search_vaccine_immunogenicity_failures

search_failed_adcs

search_adc_linker_failures

search_failed_bispecifics

search_bispecific_format_failures

search_admet_failures_all_modalities

search_drug_drug_interaction_failures

search_mechanism_failures

search_failed_replications

search_safety_failures

search_target_history

search_indication_history

search_pathogen_history

get_compound

get_finding_provenance

get_target_landscape

list_top_targets

list_models

get_model_card

get_coverage

Install

Remote endpoint

Related servers