MSDS Chain MCP Server
Chemical safety intelligence for AI-assisted experiment design.
Powered by ChainSDS — a verified, always-current chemical safety database. Verified. Current. Growing.
An MCP server that gives AI agents (Claude Code, Cursor, Copilot, pi, etc.) access to chemical safety reasoning — compatibility checks, hazard analysis, regulatory compliance, PPE recommendations, storage guidance, and more.
Built for researchers who design experiments with AI and need safety verification integrated into their workflow.
Why This Exists
When you use Claude to plan a synthesis route or set up an Opentrons protocol, safety validation shouldn't be a separate step. This MCP server lets your AI assistant automatically:
- Check if chemicals on the same deck are compatible
- Flag dangerous mixing orders
- Recommend PPE for the specific chemicals you're handling
- Verify compliance with EU REACH, US OSHA/TSCA, and 7 other jurisdictions
- Generate signed audit reports for GLP/GMP compliance
Tools (21)
| Tool | Description |
|---|---|
batch_safety_check | One-call comprehensive report: compatibility + PPE + storage grouping for a chemical list |
check_regulatory_lists | Cross-reference a chemical against 23 regulatory watch lists across 10 regions |
get_sds_section | Retrieve a specific SDS section (1-16) for a chemical |
get_chemical_alternatives | Safer substitutes for restricted or high-risk chemicals |
validate_protocol_chemicals | Extract & validate chemical names from protocol text or code |
check_mixing_order | Safe addition sequence for reagent pairs (e.g., acid into water) |
get_waste_disposal | Waste classification, container type, and disposal procedures |
upload_msds_pdf | Upload MSDS PDF for AI-powered parsing and data extraction (requires API key) |
compare_sds_versions | Structured 7-dimension diff between SDS versions of a chemical |
check_chemical_compatibility | Pairwise compatibility for 2+ chemicals |
get_chemical_risk_warnings | GHS classification, H-codes, signal words, flash point |
get_ppe_recommendation | Gloves, eye protection, respiratory, body protection |
get_storage_guidance | Storage class, cabinet type, temperature, isolation rules |
get_emergency_response | Spill, fire, or exposure emergency procedures |
get_exposure_limits | OEL/TLV/PEL/MAC across US, EU, JP, CN, INT |
get_transport_classification | UN number, hazard class, packing group, ADR/IATA/IMDG |
check_regulatory_compliance | Multi-region: EU, US, CN, JP, KR, CA, AU, TW, SG |
search_chemical_database | Look up chemicals by name, synonym, or CAS number |
ask_chemical_safety | Natural language catch-all for any safety question |
create_audit_session | Full audit with signed PDF report (requires API key) |
get_audit_report | Download link for the signed audit PDF |
Quick Start
1. Get an API key
Sign up at msdschain.lagentbot.com → API Keys tab → create a key.
2. Install
git clone https://github.com/littleblakew/msds-chain-mcp.git
cd msds-chain-mcp
pip install -r requirements.txt
3. Add to your AI coding agent
Claude Code (Remote — recommended):
claude mcp add msds-chain --transport http https://mcp.lagentbot.com/mcp
Then run /mcp in Claude Code and authenticate — a browser opens to sign in (email
code); your account is provisioned automatically and calls are metered to you (free
plan includes a monthly free quota). The legacy SSE endpoint
(--transport sse --url https://mcp.lagentbot.com/sse) still works but streamable
HTTP is preferred.
Claude Code (Plugin — includes skill + MCP):
/plugin install https://github.com/littleblakew/msds-chain-mcp.git
Claude Code (npm — local):
claude mcp add msds-chain -- npx -y msds-chain-mcp@latest
claude.ai (Web): Search "msds-chain" in Settings > Plugins (already published).
Manual config (Claude Code ~/.claude.json):
{
"mcpServers": {
"msds-chain": {
"type": "http",
"url": "https://mcp.lagentbot.com/mcp"
}
}
}
Restart Claude Code, run /mcp, and authenticate (OAuth). You should then see
msds-chain in the MCP tools list. (Prefer a static key instead of OAuth? Pass it as
a header — --header "Authorization: Bearer sk-msds-your-key" — for headless clients.)
Claude Code Skill
The /msds-safety-check skill provides auto-detection and guided audit workflows.
Plugin install (includes skill + MCP automatically):
/plugin install https://github.com/littleblakew/msds-chain-mcp.git
Manual install (skill only, if MCP already configured):
git clone https://github.com/littleblakew/msds-chain-mcp.git /tmp/msds-chain-mcp
cp -r /tmp/msds-chain-mcp/skills/msds-safety-check .agents/skills/msds-safety-check
ln -s ../../.agents/skills/msds-safety-check .claude/skills/msds-safety-check
What the Skill Does
- Auto-detects chemicals in your conversations and offers safety checks
/msds-safety-check— guided audit for lab protocols or EHS compliance- Freemium — basic queries work without API key, audit reports require free registration
Usage Examples
Experiment Protocol Review
User: I'm planning a Grignard reaction with magnesium turnings, diethyl ether,
and bromobenzene. Check if this setup is safe.
Claude:
→ calls batch_safety_check(["magnesium", "diethyl ether", "bromobenzene"])
→ Returns: compatibility matrix, PPE requirements, storage grouping
Opentrons Deck Safety Audit
User: My Opentrons deck has these in different slots:
Slot 1: Acetone, Slot 3: Concentrated H2SO4, Slot 5: Methanol,
Slot 7: Sodium borohydride. Any safety issues?
Claude:
→ calls check_chemical_compatibility(["acetone", "sulfuric acid", "methanol", "sodium borohydride"])
→ ⚠️ INCOMPATIBLE: Sodium borohydride + sulfuric acid (violent reaction, H2 gas evolution)
→ ⚠️ CAUTION: Acetone + sulfuric acid (exothermic)
→ Recommendation: Move sodium borohydride to maximum distance from acids
Compliance Check Before Shipping
User: We need to ship toluene and dichloromethane to our Japan lab.
What transport regulations apply?
Claude:
→ calls get_transport_classification(["toluene", "dichloromethane"])
→ calls check_regulatory_compliance(["toluene", "dichloromethane"], regions=["JP"])
→ Returns: UN numbers, IATA packing instructions, Japan-specific regulations
Generate Signed Audit Report
User: Create a safety audit report for our quarterly review.
Chemicals: acetone, methanol, ethanol, isopropanol, hexane.
Claude:
→ calls create_audit_session("Q2 2026 Solvent Cabinet Review", ["acetone", "methanol", "ethanol", "isopropanol", "hexane"])
→ calls get_audit_report("SESSION-ID")
→ Returns: Signed PDF URL (Ed25519 signature, suitable for GLP/GMP compliance)
Try These Prompts (one per tool)
Each prompt reliably triggers the named tool. Use them to evaluate the connector end-to-end.
| Tool | Example prompt | What a good response shows |
|---|---|---|
search_chemical_database | "Look up the chemical with CAS 67-64-1." | Acetone identified with synonyms + CAS |
ask_chemical_safety | "Is it safe to store bleach next to ammonia?" | Plain-language hazard answer (toxic chloramine gas) |
check_chemical_compatibility | "Are acetone and hydrogen peroxide compatible?" | Pairwise verdict + reaction risk |
get_chemical_risk_warnings | "What are the GHS hazards of toluene?" | H-codes, signal word, flash point |
get_ppe_recommendation | "What PPE do I need to handle concentrated sulfuric acid?" | Gloves/eye/respiratory/body guidance |
get_storage_guidance | "How should I store sodium hydroxide and nitric acid?" | Storage class, cabinet, isolation rules |
get_emergency_response | "What do I do if I spill chloroform?" | Step-by-step spill procedure |
get_exposure_limits | "What's the OEL for benzene in the EU?" | OEL/TLV/PEL values by region |
get_transport_classification | "How is acetone classified for air freight?" | UN number, hazard class, packing group |
check_regulatory_compliance | "Is dichloromethane restricted in Japan and the EU?" | Per-region compliance status |
check_regulatory_lists | "Which regulatory watch lists include formaldehyde?" | Matched lists across regions |
get_waste_disposal | "How do I dispose of waste acetonitrile?" | Waste class, container, procedure |
check_mixing_order | "What's the safe order to mix sulfuric acid and water?" | Correct addition sequence + why |
get_chemical_alternatives | "Is there a safer substitute for hexane in extraction?" | Lower-hazard alternatives |
validate_protocol_chemicals | "Validate the chemicals in this protocol: [paste text]" | Extracted + verified chemical list |
get_sds_section | "Show me section 4 (first aid) of the SDS for methanol." | Requested SDS section content |
compare_sds_versions | "What changed between SDS versions for acetone?" | 7-dimension structured diff |
batch_safety_check | "Run a full safety check on acetone, methanol, and hexane." | Compatibility + PPE + storage report |
upload_msds_pdf | "Parse this MSDS PDF and extract its hazard data." (API key) | Structured extraction from the PDF |
create_audit_session | "Create a signed audit report for our solvent cabinet." (API key) | Audit session + signed PDF |
get_audit_report | "Give me the download link for that audit report." (API key) | Signed PDF URL |
Privacy & Data Handling
- Privacy Policy: msdschain.lagentbot.com/privacy
- Read-only tools send only the chemical names / queries you provide; no personal data is required.
- API-key tools (
upload_msds_pdf,create_audit_session,get_audit_report) associate activity with your account for audit traceability. - Uploaded MSDS PDFs are processed for data extraction and contribute to the verified ChainSDS database per your account's data-sharing settings.
Third-Party AI Platform Integration
Connect to the hosted MSDS Chain MCP server from any AI platform that supports MCP.
Server URL (preferred): https://mcp.lagentbot.com/mcp (streamable HTTP)
The hosted endpoint serves both transports — streamable HTTP (/mcp, preferred) and SSE (/sse, for clients that only speak SSE: Claude.ai, 悟空, Dify, Coze, etc.). Calls are metered per authenticated user.
| Transport | Endpoint | Notes |
|---|---|---|
| Streamable HTTP | https://mcp.lagentbot.com/mcp | Preferred — broadest, most robust |
| SSE | https://mcp.lagentbot.com/sse | For SSE-only clients |
Authentication: either OAuth (the client opens a browser sign-in on first connect) or a static header — Authorization: Bearer sk-msds-your-key — for headless clients.
悟空 (Wukong)
- 设置 → MCP 服务 → + 添加
- 类型：SSE
- 名称：
msds-chain - URL：
https://mcp.lagentbot.com/sse - HTTP Headers：
Authorization:Bearer sk-msds-your-key - 点击「添加」
Dify / Coze / other platforms
General steps:
- Find MCP server / tool integration settings
- Select SSE transport type
- Set URL to
https://mcp.lagentbot.com/sse - Add authentication header:
Authorization: Bearer sk-msds-your-key
Get an API key: Sign up at msdschain.lagentbot.com → API Keys tab → Create Key.
Remote Mode (HTTP)
For cloud deployment or shared team access, run as an HTTP server:
# Streamable HTTP (recommended for Claude Code 2026+)
MSDS_API_KEY=sk-msds-xxx python server_remote.py
# Or SSE mode
MSDS_MCP_TRANSPORT=sse MSDS_API_KEY=sk-msds-xxx python server_remote.py
Connect from Claude Code:
claude mcp add msds-chain --transport http https://your-server.example.com/mcp
Docker
docker build -t msds-chain-mcp .
docker run -p 8080:8080 -e MSDS_API_KEY=sk-msds-xxx msds-chain-mcp
Configuration
| Variable | Default | Description |
|---|---|---|
MSDS_API_KEY | (required) | API key from the MSDS Chain dashboard |
MSDS_API_URL | Production URL | For development use only |
MSDS_LANG | en | Response language: en, zh, ja, de, id |
Use Cases
Lab Automation (Opentrons / Hamilton / Tecan)
- Pre-run protocol safety audit
- Deck layout compatibility verification
- Automated run compliance reports
Electronic Lab Notebooks (Benchling / LabArchives)
- Safety annotations on experiment entries
- Chemical registration with auto-flagging
Pharmaceutical R&D
- Synthesis route safety screening
- Multi-region regulatory pre-checks for new compounds
- GMP-ready audit trail with signed receipts
Data Coverage — ChainSDS
Industry-sourced, AI-verified, and cryptographically signed.
- 4,000,000+ chemical records with multi-language aliases (EN/ZH/JA)
- NFPA/GHS classification for compatibility rules
- 23 regulatory watch lists across 10 regions (structured compliance for EU, US, CN, JP, KR, CA, AU, TW, SG)
- Occupational exposure limits from 5 standards (OSHA PEL, ACGIH TLV, EU IOELV, JP OEL, CN GBZ)
- UN transport data for 16+ common lab chemicals
- Version tracking with 7-dimension SDS diff for regulatory updates
Architecture
Your AI Agent MSDS Chain MCP Server
┌──────────────────┐ ┌─────────────────────────┐
│ Claude Code │ │ 21 Safety Tools │
│ Cursor / pi │──MCP────▶│ ↓ │
│ Any MCP client │ │ ChainSDS Platform │
└──────────────────┘ └─────────────────────────┘
The MCP server connects to the ChainSDS platform for verified safety reasoning.
Development
Test locally with the MCP inspector:
export MSDS_API_KEY=sk-msds-your-key
npx @modelcontextprotocol/inspector python server.py
Troubleshooting
| Symptom | Likely cause | Fix |
|---|---|---|
401 Unauthorized on connect | Missing or invalid API key | Verify the Authorization: Bearer sk-msds-... header (or MSDS_API_KEY env var). Generate a fresh key at msdschain.lagentbot.com → API Keys. |
| Tools don't appear in the client | MCP server not loaded | Fully restart the client after adding the server. Confirm msds-chain shows in the MCP/tools list. |
| Connection drops or times out | Wrong transport / endpoint | Use the SSE endpoint https://mcp.lagentbot.com/sse. Check GET /health returns {"status":"ok"}. |
Quota exceeded / 429 | Monthly call limit hit | Free keys are limited; upgrade your plan or wait for the monthly reset. |
| Empty results for a known chemical | Name not matched | Retry with the CAS number or a common synonym; search_chemical_database accepts name, synonym, or CAS. |
| OAuth login fails in a browser client | OAuth metadata unreachable | Confirm GET /.well-known/oauth-authorization-server returns 200; the client should auto-discover the authorize/token endpoints. |
Still stuck? Email contact@lagentbot.com or open an issue at github.com/littleblakew/msds-chain-mcp/issues.
Roadmap
-
get_waste_disposal— waste classification and disposal guidance -
check_mixing_order— safe addition sequence for reagent pairs -
get_chemical_alternatives— safer substitutes for restricted chemicals - Remote MCP (HTTP SSE / Streamable HTTP) for cloud-hosted access
- OAuth 2.1 for Claude Marketplace integration
License
MIT
About
Built by LAgentBot — AI-powered chemical safety infrastructure.
Part of the MSDS Chain platform — the world's first AI Agent-driven chemical safety data trust network, powered by ChainSDS: verified, current, and growing.