🧬 ARIA Clinical Research MCP Server
A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required.
Tools
| Tool | Description |
|---|---|
search_pubmed | Search 35M+ peer-reviewed papers via NCBI E-utilities |
search_clinical_trials | Search 400K+ trials via ClinicalTrials.gov v2 API |
search_isrctn | Search UK/European trials via ISRCTN registry |
Prompts
| Prompt | Description |
|---|---|
clinical-research-brief | Comprehensive evidence + trial brief for a condition |
adverse-event-analysis | Structured AE and safety profile for a drug |
trial-eligibility-checker | Patient eligibility assessment across recruiting trials |
Resources
| Resource | Description |
|---|---|
info://aria | Overview of ARIA capabilities and data sources |
reference://trial-phases | Phase I–IV definitions and FDA special designations |
reference://high-impact-journals | Curated high-impact journals by specialty |
reference://fda-databases | FDA databases for drug, safety, and regulatory research |
Example queries
Once connected, ask Claude:
- "Search PubMed for ketogenic diet pediatric epilepsy outcomes"
- "Find recruiting trials for lung cancer immunotherapy"
- "What does the literature say about veliparib in ovarian cancer, and are there active trials?"
- "Find UK and European trials for pediatric epilepsy via ISRCTN"
Quickstart
pip install aria-mcp-server
aria-mcp-server
Connect to Claude Desktop
Add to ~/Library/Application Support/Claude/claude_desktop_config.json:
{
"mcpServers": {
"aria-clinical-research": {
"command": "aria-mcp-server"
}
}
}
Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.
Data sources
- PubMed — NCBI E-utilities (public API, no key required)
- ClinicalTrials.gov — v2 REST API (public API, no key required)
- ISRCTN — UK/European clinical trials registry (public API, no key required)
Tech stack
- FastMCP — MCP server framework
- Python 3.12+
Use cases
- Life sciences researchers needing real-time literature access
- Clinical trial coordinators checking eligibility and recruiting status
- Drug discovery teams cross-referencing published evidence with active trials
- Any Claude agent needing grounded biomedical knowledge
Project Structure
aria-mcp-server/ ← root, where mcp-publisher runs
├── aria_mcp_server/ ← Python package
│ ├── __init__.py
│ ├── server.py
│ └── tools.py
├── server.json ← MCP registry metadata
├── pyproject.toml
├── README.md
├── LICENSE
└── glama.json
Built by
Pooja Kotecha · dinq.me/pkotecha-eng